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Ofatumumab promising in refractory follicular lymphoma    Jul 22, 2008
NEW YORK (Reuters Health) - The human monoclonal antibody ofatumumab was well tolerated by patients with relapsed or refractory follicular non-Hodgkin's lymphoma in a Phase 1 / 2 safety and efficacy trial, according to European researchers.
Most foreign-born TB patients in US from sub-Saharan Africa, SE Asia    Jul 22, 2008
NEW YORK (Reuters Health) - Between 2001-2006, 53% of the tuberculosis cases that occurred among foreign-born individuals in the US involved persons from sub-Saharan Africa or Southeast Asia, new research indicates.
Low mass islet cell transplants achieve insulin independence    Jul 22, 2008
NEW YORK (Reuters Health) - Allogeneic islet cell transplantation outcome is improved with smaller transplant size and with addition of etanercept and exenatide to the post-transplant immunosuppression regimen.
U.S. FDA, CDC say Merck's Gardasil shot remains safe    Jul 22, 2008
WASHINGTON (Reuters) - A review of health problems reported after women and girls received Merck & Co's Gardasil vaccine shows it remains safe and effective for protecting against a virus that causes cervical cancer, U.S. officials said on Tuesday.
CMV reactivation common in critically ill, immunocompetent patients    Jul 22, 2008
NEW YORK (Reuters Health) - Critically ill patients with intact immune systems frequently experience cytomegalovirus (CMV) reactivation, with the reactivation independently linked to prolonged hospitalization or death.
Omeprazole boosts saquinavir exposure in HIV patients    Jul 22, 2008
NEW YORK (Reuters Health) - In HIV patients taking saquinavir/ritonavir, use of omeprazole leads to a significant - and apparently well tolerated - increase in saquinavir plasma exposure.
Sildenafil improves antidepressant-associated sexual dysfunction in women    Jul 22, 2008
NEW YORK (Reuters Health) - Sildenafil is an effective treatment for women with sexual dysfunction associated with serotonin reuptake inhibitors, according to a prospective study published in the July 23/30 issue of the Journal of the American Medical Association.
Multi-drug resistance emerging in pneumococcal mastoiditis    Jul 22, 2008
NEW YORK (Reuters Health) - The Streptococcus pneumoniae serotype that most often causes mastoiditis in children is becoming increasingly drug-resistant.
Depression linked with increased risk for first stroke in elderly    Jul 22, 2008
NEW YORK (Reuters Health) - A study in the July issue of Stroke suggests an association between depression and an increased risk for first-ever stroke in elderly subjects.
Direct emergency admission to catheterization lab reduces time to intervention    Jul 22, 2008
NEW YORK (Reuters Health) - Direct ambulance admission to the cardiac catheterization laboratory significantly reduces the time to performance of primary percutaneous intervention (PCI), according to a report in the June issue of the American Heart Journal.
Inhaled mannitol improves lung function in cystic fibrosis patients    Jul 22, 2008
NEW YORK (Reuters Health) - Treatment with inhaled mannitol leads to significantly improved lung function in patients with cystic fibrosis (CF), according to a report by Australian researchers in the June issue of Chest.
Sperm motility before varicocele treatment predicts pregnancy    Jul 22, 2008
NEW YORK (Reuters Health) - In infertile men undergoing varicocele embolization, sperm motility before treatment predicts their odds of siring a pregnancy, according to a report in the August issue of Radiology.
Maximizing HAART coverage has potential to curb HIV epidemic    Jul 22, 2008
NEW YORK (Reuters Health) - Treatment of at least 75% of individuals who are eligible for treatment of human immunodeficiency virus (HIV) infection with highly active antiretroviral therapy (HAART) has the potential to "curb the growth of the HIV epidemic," Canadian researchers announce.
Serious adverse outcomes uncommon after glaucoma surgery: study    Jul 21, 2008
NEW YORK (Reuters Health) - Although severe adverse outcomes are uncommon after incisional filtering surgery for glaucoma, the risk of adverse outcomes is higher after implantation of a glaucoma drainage device (GDD) than after primary trabeculectomy (PT). The rate of severe adverse outcomes with PT, however, is similar to that with trabeculectomy in the presence of scarring (TS) from previous ocular surgery or trauma.
Gadolinium-based contrast raises nephrogenic systemic fibrosis risk    Jul 21, 2008
NEW YORK (Reuters Health) - Gadolinium-based contrast material used in magnetic resonance imaging (MRI) increases the risk for nephrogenic systemic fibrosis (NSF), according to a report in the June issue of the American Journal of Kidney Diseases.
Obstructive sleep apnea may trigger nocturnal MI    Jul 21, 2008
NEW YORK (Reuters Health) - The hemodynamic and neurohormonal changes wrought by obstructive sleep apnea (OSA) may increase the risk of MI during the night, new research suggests.
Sunscreen may prevent hypopigmentation after CO2 laser resurfacing    Jul 21, 2008
NEW YORK (Reuters Health) - Carbon dioxide (CO2) laser resurfacing is a safe and effective long-term treatment for facial wrinkles and solar aging, physicians report in the July/August issue of the Archives of Facial Plastic Surgery. Hypopigmentation - the single complication they observed in patients more than two years after treatment - can be minimized by using sunscreen before and after the procedure.
Gene expression profiles with clinical data prognostic for early stage lung cancer    Jul 21, 2008
NEW YORK (Reuters Health) - Gene expression signatures predict survival in patients with early stage lung cancer, particularly when combined with clinical data, scientists report in the July 20 online issue of Nature Medicine. The researchers' comparison of several models showed that gene cluster expression analysis performed best.
Topiramate linked to birth defects    Jul 21, 2008
NEW YORK (Reuters Health) - The antiepileptic drug topiramate (Topamax) has been linked with an increased risk of major congenital malformations when taken during pregnancy, investigators report in the July 22 issue of Neurology.
NT-proBNP predicts patent ductus arteriosus in preterm babies    Jul 21, 2008
NEW YORK (Reuters Health) - Plasma level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a practical indicator of significant patent ductus arteriosus in preterm infants, Irish researchers report in the July issue of Archives of Disease in Childhood -- Fetal and Neonatal Edition.
Bivalent CMV DNA vaccine shows promise in phase 1 trial    Jul 21, 2008
NEW YORK (Reuters Health) -- A bivalent DNA vaccine against cytomegalovirus (CMV) has immunogenic potential and appears to be safe in healthy CMV-seropositive and -seronegative adults, according to results of a phase 1, multicenter, open-label, dose-escalating trial reported in the June 15 issue of the Journal of Infectious Diseases.
Diabetes is associated with left ventricular hypertrophy    Jul 21, 2008
NEW YORK (Reuters Health) - Results of a study published in the June 15th issue of the American Journal of Cardiology suggest an independent association between type 2 diabetes mellitus and increased left ventricular hypertrophy.
Adolescents, an underserved group, have low immunization rates    Jul 21, 2008
NEW YORK (Reuters Health) - Many adolescents do not receive recommended immunizations, the National Vaccine Advisory Committee (NVAC) reports. In fact, preventive healthcare, in general, is lacking in this age group, even if health insurance and access to healthcare is available, NVAC members say in the August issue of the American Journal of Preventive Medicine.
Resistance exercise training beneficial in Asian Indian diabetics    Jul 21, 2008
NEW YORK (Reuters Health) - Progressive resistance training improves insulin sensitivity, glycemic control and lipid levels and reduces subcutaneous adipose tissue deposits in Asian Indian patients with type II diabetes, researchers from India report in the July issue of Diabetes Care.
Immunotherapy may boost prostate cancer response to hormone therapy    Jul 21, 2008
NEW YORK (Reuters Health) - Patients with nonmetastatic castration-resistant prostate cancer (stage D0.5) treated with an experimental vaccine targeting prostate specific antigen (PSA) subsequently showed clinical response to second-line hormone therapy, according to a long-term follow-up study of a phase II clinical trial.

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